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Dosage and Administration
The dose of ARIMIDEX (Anastrozole) is one 1 mg tablet taken once a day. For patients with advanced breast cancer, ARIMIDEX(Anastrozole) should be continued until tumor progression. ARIMIDEX (Anastrozole) can be taken with or without food.
For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, ARIMIDEX(Anastrozole) was administered for five years
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How to use Arimidex 1 Mg Tablet Aromatase Inhibitors
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.
ARIMIDEX(Anastrozole) may cause fetal harm when administered to a pregnant woman and offers no clinical benefit to premenopausal women with breast cancer. ARIMIDEX(Anastrozole) is contraindicated in women who are or may become pregnant. There are no adequate and well-controlled studies in pregnant women using ARIMIDEX(Anastrozole)If ARIMIDEX(Anastrozole) is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus or potential risk for loss of the pregnancy.
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Arimidex is one of the meds used in hormone therapy of breast cancer. Being a non-steroidal inhibitor of aromatase, an enzyme that converts androgens into estrogens, Arimidex reduces the estrogen level in postmenopausal women. Women with high estrogen level (female sex hormone) in the blood are thought to be at an increased risk of being diagnosed with breast cancer.
Arimidex is characterized by antitumor activity and is indicated to postmenopausal women for the treatment of:
- hormone receptor-positive early breast cancer
- hormone receptor-positive advanced breast cancer
- advanced breast cancer with disease progression following tamoxifen therapy
The recommended daily dose of Arimidex is 1 mg (1 pill) once a day for adults and elderly patients. In case of progression, the intake of Arimidex pills is recommended to be stopped. If patients suffer from mild to moderate renal and liver disorders, they do not need yet to adjust the dose of Arimidex.
If the patient missed a scheduled dose of Arimidex, an anticancer drug, she should take it as soon as possible, but not if more than 12 hours passed since the missed dose. If it is the nearly time for the next dose, the patient is recommended to skip the missed dose of Arimidex, aromatase inhibitor. The next daily dose is to be taken normally (no double, at the same time).
Arimidex tablets are swallowed whole and taken irrespective of meals at the same time. Treatment with Arimidex in patients, previously taken tamoxifen, should be started after completion of 2-3 year’s tamoxifen therapy. During treatment with Arimidex, patients should not be indicated with drugs containing estrogen, since these drugs reduce the pharmacological action of the aromatase inhibitor.
Arimidex tablets should be protected from moisture and rapid temperature changes. This non-steroidal aromatase inhibitor is recommended to be kept in the original packaging at temperature of 20°C to 25°C.
Arimidex safety information
Coadministration of Arimidex with drugs containing tamoxifen is not recommended since the pharmacological effect of Arimidex can be decreased. Caution should be taken whilst prescribing the non-steroidal aromatase inhibitor to patients with osteoporosis or at risk for osteoporosis because Arimidex may reduce bone mineral density.
Clinical studies have demonstrated that Arimidex does not result in significant drug interaction with antipyrin, warfarin, or cimetidine. There are no eligible data available on the efficacy of the combined use of Arimidex with chemotherapy.
Caution is recommended while driving a motor vehicle and operating mechanisms, as some side effects of Arimidex (drowsiness, chronic fatigue syndrome) may adversely affect the ability to concentrate. In case of overdose, the symptomatic treatment is recommended since there is no specific antidote available at the pharmaceutical market.
Information about Arimidex and treatment of breast cancer in women are provided herein for information purposes only. Overview of the anti-cancer drug should not be used to replace consultation with the oncologist. The Online Pharmacy shall not be responsible for any errors or omissions with regards to the information or any losses, injuries, or damages arising from use of the review of antineoplastic agent Arimidex.
Arimidex side effects
Undesirable effects, which may sometimes occur when taking Arimidex tablets, more often do not lead to any complications and do not result in the cessation of drug therapy. Basically, these easily tolerable undesirable effects pass fast enough. Undesirable effects, caused by Arimidex, mostly (more than 10% of cases) include vomiting, diarrhea, nausea, alopecia, vaginal dryness, and hypertension.
Sleep disturbances, headache, depression and asthenia may be experienced as well. The use of Arimidex may cause some musculoskeletal system diseases, such as arthritis, osteoporosis, myalgia, bone pain, arthralgia, and joint stiffness. Also sensory disorders, such as taste loss or perversion, paraesthesia are possible.
Cholesterol: During the ATAC trial, more patients receiving ARIMIDEX(Anastrozole) were reported to have elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively).
Ischemic Cardiovascular Events In women with pre-existing ischemic heart disease, an increased incidence of ischemic cardiovascular events was observed with ARIMIDEX(Anastrozole) in the ATAC trial (17% of patients on ARIMIDEX and 10% of patients on tamoxifen). Consider risk and benefits of ARIMIDEX therapy in patients with pre-existing ischemic heart disease.
Bone Effects: Results from the ATAC trial bone substudy at 12 and 24 months demonstrated that patients receiving ARIMIDEX(Anastrozole) had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline more info :
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